Stem Cells, Vol 13, 380-392, Copyright © 1995 by AlphaMed Press

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Tyrosine kinases in megakaryocytopoiesis

H Avraham, MH Ellis, BH Jhun, S Raja, D Chalasani and S Avraham
Division of Hematology/Oncology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

Protein-tyrosine kinases (PTKs) are of vital importance in a variety of cell functions. Recent studies have provided considerable insight into the binding of growth factors to tyrosine kinase receptors and the consequent induction of signal pathways that lead to a biologic response. Future studies will further delineate the signals that result in a proliferative response and those that induce a differentiation response. Current studies, reviewed here, indicate an important biologic role for PTKs in the regulation of megakaryocyte development and maturation. Whether PTKs function in megakaryocytes in signaling pathways that are similar to pathways in other cells will need to be examined in future studies.

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				D. Hiregowdara, H. Avraham, Y. Fu, R. London, and S. Avraham Tyrosine Phosphorylation of the Related Adhesion Focal Tyrosine Kinase in Megakaryocytes upon Stem Cell Factor and Phorbol Myristate Acetate Stimulation and Its Association with Paxillin J. Biol. Chem., April 18, 1997; 272(16): 10804 - 10810. [Abstract] [Full Text] [PDF]