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-Chain in Adult and Embryonic Tissues
a Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand;
b Genetics Institute, Inc., Cambridge, Massachusetts, USA
Key Words. Interleukin 11 • ES cells • IL-11 receptor 
-chain • Embryonic development
Dr. Philip Crosier, Department of Molecular Medicine, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Interleukin 11 (IL-11) is a multifunctional cytokine that has diverse effects on blood cells and their precursors and on a number of cell types outside of the hematopoietic system. The cDNAs encoding murine IL-11 and its receptor
-chain (IL-11R) have recently been isolated. We have used the RNase protection assay to examine the expression of murine IL-11 and IL-11R in a range of adult mouse tissues, in embryos, and during development of embryonic stem (ES) cells into cystic embryoid bodies in vitro. The testis showed a high level of IL-11 gene expression while a much lower level of expression was detected in the lung, stomach, small intestine, and large intestine. Expression of IL-11 was not detected between day 10.5 and day 18.5 post coitum of embryonic development or in differentiating ES cells in vitro. In contrast, the IL-11R was found to be expressed in all adult tissues examined, during embryonic development, and in totipotent and differentiating ES cells.
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