| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Concise Reviews |
a The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia;
b Schering-Plough Laboratory for Immunological Research, Dardilly, France
Key Words. Antigen-presenting cells • Dendritic cells • Lymphoid-related dendritic cells • Myeloid-related dendritic cells • Langerhans' cells
Dr. Ken Shortman, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.
Dendritic cells are a system of bone marrow-derived antigen-presenting cells specialized for interaction with T lymphocytes and essential for initiating primary T cell immune responses. Recent investigation indicates that dendritic cells are of diverse origin, with at least two types of myeloid precursors and a lymphoid precursor implicated in their generation. Mature dendritic cell subtypes, while sharing the capacity to activate T cells, show additional functional specialization. Some dendritic cells are equipped with additional mechanisms to regulate the response of the T cells they activate, while others are able to interact with B cells and modify B cell responses.
This article has been cited by other articles:
|
|
 |
|
  P. F. Moore, V. K. Affolter, and W. Vernau Canine Hemophagocytic Histiocytic Sarcoma: A Proliferative Disorder of CD11d+ Macrophages. Vet. Pathol., September 1, 2006; 43(5): 632 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Affolter and P. F. Moore Feline progressive histiocytosis. Vet. Pathol., September 1, 2006; 43(5): 646 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. I. Slukvin, M. A. Vodyanik, J. A. Thomson, M. E. Gumenyuk, and K.-D. Choi Directed Differentiation of Human Embryonic Stem Cells into Functional Dendritic Cells through the Myeloid Pathway. J. Immunol., March 1, 2006; 176(5): 2924 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Esashi, H. Ito, K. Ishihara, T. Hirano, S. Koyasu, and A. Miyajima Development of CD4+ Macrophages from Intrathymic T Cell Progenitors Is Induced by Thymic Epithelial Cells J. Immunol., October 1, 2004; 173(7): 4360 - 4367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Encabo, P. Solves, E. Mateu, P. Sepulveda, F. Carbonell-Uberos, and M. D. Minana Selective Generation of Different Dendritic Cell Precursors from CD34+ Cells by Interleukin-6 and Interleukin-3 Stem Cells, September 1, 2004; 22(5): 725 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Belz, C. M. Smith, D. Eichner, K. Shortman, G. Karupiah, F. R. Carbone, and W. R. Heath Cutting Edge: Conventional CD8{alpha}+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses J. Immunol., February 15, 2004; 172(4): 1996 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Esashi, T. Sekiguchi, H. Ito, S. Koyasu, and A. Miyajima Cutting Edge: A Possible Role for CD4+ Thymic Macrophages as Professional Scavengers of Apoptotic Thymocytes J. Immunol., September 15, 2003; 171(6): 2773 - 2777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hamrah, L. Chen, Q. Zhang, and M. R. Dana Novel Expression of Vascular Endothelial Growth Factor Receptor (VEGFR)-3 and VEGF-C on Corneal Dendritic Cells Am. J. Pathol., July 1, 2003; 163(1): 57 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Ackerman and P. Cresswell Regulation of MHC Class I Transport in Human Dendritic Cells and the Dendritic-Like Cell Line KG-1 J. Immunol., April 15, 2003; 170(8): 4178 - 4188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Puig-Kroger, O. Muniz-Pello, R. Selgas, G. Criado, M-A. Bajo, J. A. Sanchez-Tomero, V. Alvarez, G. del Peso, P. Sanchez-Mateos, C. Holmes, et al. Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradation products J. Leukoc. Biol., April 1, 2003; 73(4): 482 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schotte, M.-C. Rissoan, N. Bendriss-Vermare, J.-M. Bridon, T. Duhen, K. Weijer, F. Briere, and H. Spits The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development Blood, February 1, 2003; 101(3): 1015 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ferrero, W. Held, A. Wilson, F. Tacchini-Cottier, F. Radtke, and H. R. MacDonald Mouse CD11c+ B220+ Gr1+ plasmacytoid dendritic cells develop independently of the T-cell lineage Blood, September 26, 2002; 100(8): 2852 - 2857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fallarino, U. Grohmann, C. Vacca, R. Bianchi, M. C. Fioretti, and P. Puccetti CD40 Ligand and CTLA-4 Are Reciprocally Regulated in the Th1 Cell Proliferative Response Sustained by CD8+ Dendritic Cells J. Immunol., August 1, 2002; 169(3): 1182 - 1188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Affolter and P. F. Moore Localized and Disseminated Histiocytic Sarcoma of Dendritic Cell Origin in Dogs Vet. Pathol., January 1, 2002; 39(1): 74 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wu, A. D'Amico, H. Hochrein, M. O'Keeffe, K. Shortman, and K. Lucas Development of thymic and splenic dendritic cell populations from different hemopoietic precursors Blood, December 1, 2001; 98(12): 3376 - 3382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Dieu-Nosjean, C. Massacrier, B. Vanbervliet, W.-H. Fridman, and C. Caux IL-10 Induces CCR6 Expression During Langerhans Cell Development While IL-4 and IFN-{gamma} Suppress It J. Immunol., November 15, 2001; 167(10): 5594 - 5602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Caminschi, K. M. Lucas, M. A. O'Keeffe, H. Hochrein, Y. Laabi, F. Kontgen, A. M. Lew, K. Shortman, and M. D. Wright Molecular Cloning of F4/80-Like-Receptor, a Seven-Span Membrane Protein Expressed Differentially by Dendritic Cell and Monocyte-Macrophage Subpopulations J. Immunol., October 1, 2001; 167(7): 3570 - 3576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Puig-Kroger, M. Relloso, O. Fernandez-Capetillo, A. Zubiaga, A. Silva, C. Bernabeu, and A. L. Corbi Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells Blood, October 1, 2001; 98(7): 2175 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Santiago-Schwarz, P. Anand, S. Liu, and S. E. Carsons Dendritic Cells (DCs) in Rheumatoid Arthritis (RA): Progenitor Cells and Soluble Factors Contained in RA Synovial Fluid Yield a Subset of Myeloid DCs That Preferentially Activate Th1 Inflammatory-Type Responses J. Immunol., August 1, 2001; 167(3): 1758 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Traver, T. Miyamoto, J. Christensen, J. Iwasaki-Arai, K. Akashi, and I. L. Weissman Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets Blood, August 1, 2001; 98(3): 627 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Henri, D. Vremec, A. Kamath, J. Waithman, S. Williams, C. Benoist, K. Burnham, S. Saeland, E. Handman, and K. Shortman The Dendritic Cell Populations of Mouse Lymph Nodes J. Immunol., July 15, 2001; 167(2): 741 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.B. Toews Cytokines and the lung Eur. Respir. J., July 2, 2001; 18(34_suppl): 3S - 17s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Manz, D. Traver, T. Miyamoto, I. L. Weissman, and K. Akashi Dendritic cell potentials of early lymphoid and myeloid progenitors Blood, June 1, 2001; 97(11): 3333 - 3341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Griffin, W. Lutz, V. A. Phan, L. A. Bachman, D. J. McKean, and R. Kumar Dendritic cell modulation by 1alpha ,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo PNAS, May 18, 2001; (2001) 121172198. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Yoshimura, J. Bondeson, B. M. J. Foxwell, F. M. Brennan, and M. Feldmann Effective antigen presentation by dendritic cells is NF-{{kappa}}B dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines Int. Immunol., May 1, 2001; 13(5): 675 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iwasaki and B. L. Kelsall Unique Functions of CD11b+, CD8{{alpha}}+, and Double-Negative Peyer's Patch Dendritic Cells J. Immunol., April 15, 2001; 166(8): 4884 - 4890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Martinon-Ego, R. Berthier, F. Cretin, V. Collin, A.-M. Laharie, and P. N. Marche Murine Dendritic Cells Derived from Myeloid Progenitors of the Thymus Are Unable to Produce Bioactive IL-12p70 J. Immunol., April 15, 2001; 166(8): 5008 - 5017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kronin, C. J. Fitzmaurice, I. Caminschi, K. Shortman, D. C. Jackson, and L. E. Brown Differential effect of CD8+ and CD8- dendritic cells in the stimulation of secondary CD4+ T cells Int. Immunol., April 1, 2001; 13(4): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Traver, K. Akashi, M. Manz, M. Merad, T. Miyamoto, E. G. Engleman, and I. L. Weissman Development of CD8{alpha}-Positive Dendritic Cells from a Common Myeloid Progenitor Science, December 15, 2000; 290(5499): 2152 - 2154. [Abstract] [Full Text]
|
|
|
|
|
|
G. J. M. Maestroni Dendritic Cell Migration Controlled by {alpha}1b-Adrenergic Receptors J. Immunol., December 15, 2000; 165(12): 6743 - 6747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Kamath, J. Pooley, M. A. O'Keeffe, D. Vremec, Y. Zhan, A. M. Lew, A. D'Amico, L. Wu, D. F. Tough, and K. Shortman The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations J. Immunol., December 15, 2000; 165(12): 6762 - 6770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ruedl, P. Koebel, M. Bachmann, M. Hess, and K. Karjalainen Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes J. Immunol., November 1, 2000; 165(9): 4910 - 4916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Puig-Kroger, F. Sanz-Rodriguez, N. Longo, P. Sanchez-Mateos, L. Botella, J. Teixido, C. Bernabeu, and A. L. Corbi Maturation-Dependent Expression and Function of the CD49d Integrin on Monocyte-Derived Human Dendritic Cells J. Immunol., October 15, 2000; 165(8): 4338 - 4345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Martin, G. M. del Hoyo, F. Anjuere, S. R. Ruiz, C. F. Arias, A. R. Marin, and C. Ardavin Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8alpha - and CD8alpha + dendritic cells are generated from CD4low lymphoid-committed precursors Blood, October 1, 2000; 96(7): 2511 - 2519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Dieu-Nosjean, C. Massacrier, B. Homey, B. Vanbervliet, J.-J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, et al. Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors J. Exp. Med., September 5, 2000; 192(5): 705 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Anjuere, G. M. del Hoyo, P. Martin, and C. Ardavin Langerhans cells develop from a lymphoid-committed precursor Blood, September 1, 2000; 96(5): 1633 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sato, S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja CC Chemokine Receptor (CCR)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-inducing Dendritic Cells: Absence of CCR2 Shifts the Leishmania major-resistant Phenotype to a Susceptible State Dominated by Th2 Cytokines, B Cell Outgrowth, and Sustained Neutrophilic Inflammation J. Exp. Med., July 10, 2000; 192(2): 205 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Daro, B. Pulendran, K. Brasel, M. Teepe, D. Pettit, D. H. Lynch, D. Vremec, L. Robb, K. Shortman, H. J. McKenna, et al. Polyethylene Glycol-Modified GM-CSF Expands CD11bhighCD11chigh But Not CD11blowCD11chigh Murine Dendritic Cells In Vivo: A Comparative Analysis with Flt3 Ligand J. Immunol., July 1, 2000; 165(1): 49 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kronin, L. Wu, S. Gong, M. C Nussenzweig, and K. Shortman DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses Int. Immunol., May 1, 2000; 12(5): 731 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohishi, B. Varnum-Finney, D. Flowers, C. Anasetti, D. Myerson, and I. D. Bernstein Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1 Blood, May 1, 2000; 95(9): 2847 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vremec, J. Pooley, H. Hochrein, L. Wu, and K. Shortman CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen J. Immunol., March 15, 2000; 164(6): 2978 - 2986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Guerriero, P. B. Langmuir, L. M. Spain, and E. W. Scott PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells Blood, February 1, 2000; 95(3): 879 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gutiérrez-Rodríguez, E. Reyes-Maldonado, and H. Mayani Characterization of the Adherent Cells Developed in Dexter-Type Long-Term Cultures from Human Umbilical Cord Blood Stem Cells, January 1, 2000; 18(1): 46 - 52. [Abstract] [Full Text]
|
|
|
|
|
|
J. G. Cyster Chemokines and Cell Migration in Secondary Lymphoid Organs Science, December 10, 1999; 286(5447): 2098 - 2102. [Abstract] [Full Text]
|
|
|
|
|
|
E. E. M. Bates, N. Fournier, E. Garcia, J. Valladeau, I. Durand, J.-J. Pin, S. M. Zurawski, S. Patel, J. S. Abrams, S. Lebecque, et al. APCs Express DCIR, a Novel C-Type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif J. Immunol., August 15, 1999; 163(4): 1973 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Tang and J. G. Cyster Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells Science, April 30, 1999; 284(5415): 819 - 822. [Abstract] [Full Text]
|
|
|
|
|
|
J. G. Cyster Chemokines and the Homing of Dendritic Cells to the T Cell Areas of Lymphoid Organs J. Exp. Med., February 1, 1999; 189(3): 447 - 450. [Full Text] [PDF]
|
|
|
|
|
|
F. Santiago-Schwarz, M. McCarthy, J. Tucci, and S. E. Carsons Neutralization of Tumor Necrosis Factor Activity Shortly After the Onset of Dendritic Cell Hematopoiesis Reveals a Novel Mechanism for the Selective Expansion of the CD14-Dependent Dendritic Cell Pathway Blood, August 1, 1998; 92(3): 745 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Halfon, J. Ford, J. Foster, L. Dowling, L. Lucian, M. Sterling, Y. Xu, M. Weiss, M. Ikeda, D. Liggett, et al. Leukocystatin, A New Class II Cystatin Expressed Selectively by Hematopoietic Cells J. Biol. Chem., June 26, 1998; 273(26): 16400 - 16408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Griffin, W. Lutz, V. A. Phan, L. A. Bachman, D. J. McKean, and R. Kumar Dendritic cell modulation by 1alpha ,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo PNAS, June 5, 2001; 98(12): 6800 - 6805. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
