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The Challenge of p53: Linking Biochemistry, Biology, and Patient Management

Department of Cellular and Molecular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK

Key Words. p53 • Stress responses • Physiology • Biochemistry • Therapy

Dr. Peter A. Hall, Department of Cellular and Molecular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK.

Abnormalities of the p53 tumor suppressor gene are the single most common molecular abnormality seen in human cancer. Considerable evidence indicates that the product of this gene has critical roles in coordinating the response of cells to a diverse range of environmental stresses. At present, there is a gamut of biochemical properties and interactions ascribed to p53, but the in vivo physiological relevance of many of these remains uncertain. The development of clinical applications and novel therapeutic strategies utilizing our knowledge of p53 is contingent upon bridging the gap between rigorous biochemistry and holistic in vivo studies.

This article has been cited by other articles:

				P. A. Hall, S. J. Campbell, M. O'neill, D. J. Royston, K. Nylander, F. A. Carey, and N. M. Kernohan Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in normal and neoplasticcells Carcinogenesis, February 1, 2000; 21(2): 153 - 160. [Abstract] [Full Text] [PDF]

				P. A. Hall p53: The Challenge of Linking Basic Science and Patient Management Oncologist, August 1, 1998; 3(4): 218 - 224. [Abstract] [Full Text]