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Macrophage Colony-Stimulating Factor (M-CSF), As Well As Granulocyte Colony-Stimulating Factor (G-CSF), Accelerates Neovascularization

^a First Department of Pathology,
^b Department of Ophthalmology,
^c Regeneration Research Center for Intractable Diseases,
^d Department of Anatomical Pathology,
^e Second Department of Internal Medicine, and
^f Department of Neurology, Kansai Medical University, Moriguchi, Osaka, Japan

Key Words. Bone marrow cell • G-CSF • M-CSF • Neovascularization

Correspondence: Susumu Ikehara, M.D., Ph.D., First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, 570-8507, Japan. Telephone: 81-066-992-1001(ex. 2470); FAX 81-066-992-1219; e-mail: ikehara{at}takii.kmu.ac.jp

It has been reported that bone marrow cells (BMCs) differentiate into endothelial cells of blood vessels, and that granulocyte colony-stimulating factor (G-CSF) mobilizes progenitors in the BMCs to the peripheral blood, while macrophage colony-stimulating factor (M-CSF) augments the production of monocytes. We examined whether M-CSF augments the differentiation of BMCs into endothelial cells of blood vessels using a hindlimb-ischemic model. Either G-CSF or M-CSF, or both, was administered to the hindlimb-ischemic mice for 3 days. Both M-CSF and G-CSF augmented the differentiation of BMCs into endothelial cells of blood vessels through vascular endothelial cell growth factor (VEGF), resulting in early recovery of blood flow in the ischemic limbs.

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