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Stem Cells 2005;23:383-391 www.StemCells.com
© 2005 AlphaMed Press

Neurons Derived From Human Mesenchymal Stem Cells Show Synaptic Transmission and Can Be Induced to Produce the Neurotransmitter Substance P by Interleukin-1{alpha}

Kyung Jin Choa,c, Katarzyna A. Trzaskaa, Steven J. Grecoa, Joseph McArdleb, Fu Shun Wangb, Jiang-Hong Yeb, Pranela Rameshwara

a Department of Medicine, Hematology/Oncology and Graduate School of Biomedical Science-Interdisciplinary Program and
b Department of Pharmacology and Physiology, Anesthesiology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA;
c Department of Clinical Laboratory Science, Korea University, Seoul, Korea

Key Words. Mesenchymal stem cells • Transdifferentiation • Preprotachykinin-I • Neurons

Correspondence: Pranela Rameshwar, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA. Telephone: 973-972-0625; fax: 973-972-8854; e-mail: rameshwa{at}umdnj.edu

Mesenchymal stem cells (MSCs) exhibit immune-suppressive properties, follow a pattern of multilineage differentiation, and exhibit transdifferentiation potential. Ease in expansion from adult bone marrow, as well as its separation from ethical issues, makes MSCs appealing for clinical application. MSCs treated with retinoic acid resulted in synaptic transmission, based on immunostaining of synaptophysin and electrophysiological studies. In situ hybridization indicated that the neurotransmitter gene preprotachykinin-I was expressed in these cells. However, translation of this gene only occurred after stimulation with interleukin (IL)-1{alpha}. This effect was blunted by costimulation with IL-1 receptor antagonist. This study reports on the ability of MSCs to be transdifferentiated into neurons with functional synapses with the potential to become polarized towards producing specific neurotransmitters.




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