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Stem Cells 2005;23:463-470 www.StemCells.com
© 2005 AlphaMed Press

RAPID COMMUNICATIONS

Portal Application of Autologous CD133+ Bone Marrow Cells to the Liver: A Novel Concept to Support Hepatic Regeneration

Jan Schulte am Esch, IIa, Wolfram Trudo Knoefela, Michael Kleinb, Ali Ghodsizadb, Guenter Fuerstc, Ludger W. Pollc, Christoph Piechaczekb, Elmar R. Burchardtf, Niko Feifelb, Volker Stoldtd, Marcus Stockschläderd, Nikolas Stoeckleina, Roy Y. Tustasa, Claus F. Eisenbergera, Matthias Peipera, Dieter Häussingere, Stefan B. Hoscha

a Departments of General Surgery,
b Cardiothoracic Surgery,
c Diagnostic Radiology,
d Hemostaseology and Transfusion Medicine, and
e Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany,
f Institute of Clinical Pharmacology, University of Witten/Herdecke, Witten, Germany

Key Words. Adult bone marrow stem cells • Liver regeneration • AC133 antigen • Somatic cell therapy • Clinical trials • Clinical stem cell transplantation

Correspondence: Wolfram Trudo Knoefel, M.D., F.A.C.S., Department of General Surgery, Heinrich-Heine-University of Duesseldorf, Moorenstrasse 5, D-40225 Duesseldorf, Germany. Telephone: 49-211-8117350/51; Fax: 49-211-8117359; e-mail: knoefel{at}uni-duesseldorf.de

The liver has a large capacity for regeneration after resection. However, below a critical level of future liver remnant volume (FLRV), partial hepatectomy is accompanied by a significant increase of postoperative liver failure. There is accumulating evidence for the contribution of bone marrow stem cells (BMSCs) to participate in liver regeneration. Here we report on three patients subjected to intraportal administration of autologous CD133+ BMSCs subsequent to portal venous embolization of right liver segments, used to expand left lateral hepatic segments as FLRV. Computerized tomography scan volumetry revealed 2.5-fold increased mean proliferation rates of left lateral segments compared with a group of three consecutive patients treated without application of BMSCs. This early experience with portovenous application of CD133+ BMSCs could suggest that this novel therapeutic approach bears the potential of enhancing and accelerating hepatic regeneration in a clinical setting.




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