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RAPID COMMUNICATIONS |
a Departments of Cardiovascular Medicine and
b Advanced Clinical Science and Therapeutics, University of Tokyo Graduate School of Medicine, Tokyo, Japan;
c Department of Physiology, Keio University School of Medicine, Tokyo, Japan;
d PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan;
e CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
Key Words. Endothelial cells • Hematopoietic stem cells • Progenitor • Smooth muscle cells • Transdifferentiation
Correspondence: Masataka Sata, M.D., Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Telephone: 81-3-3815-5411; Fax: 81-3-3814-0021; e-mail: msata-circ{at}umin.ac.jp
In contrast to conventional assumption, recent reports propose the possibility that hematopoietic stem cells (HSCs) may have broader potential to differentiate into various cell types. Here, we tested the pluripotency of HSCs by comparing vascular lesions induced by mechanical injury after bone marrow reconstitution with total bone marrow (TBM) cells, c-Kit+ Sca-1+ Lin– (KSL) cells, or a single HSC cell (Tip-SP CD34–KSL cell, CD34– c-Kit+ Sca-1+ Lin– cell with the strongest dye-efflux activity) harboring green fluorescent protein (GFP). The lesions contained a significant number of GFP-positive cells in the TBM and KSL groups, whereas GFP-positive cells were rarely detected in the HSC group. These results suggest that transdifferentiation of a highly purified HSC seems to be a rare event, if it occurs at all, whereas bone marrow cells including the KSL fraction can give rise to vascular cells that substantially contribute to repair or lesion formation after mechanical injury.
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