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First published online June 22, 2006
Stem Cells Vol. 24 No. 10 October 2006, pp. 2162 -2169
doi:10.1634/stemcells.2006-0105; www.StemCells.com
© 2006 AlphaMed Press

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EMBRYONIC STEM CELLS: CHARACTERIZATION SERIES

Concise Review: Scientific and Ethical Roadblocks to Human Embryonic Stem Cell Therapy

Lori Gruena, Laura Grabelb

Departments of aPhilosophy and
bBiology, Wesleyan University, Middletown, Connecticut, USA

Key Words. Human embryonic stem cell therapy • Ethics • Oversight

Correspondence: Laura Grabel, Ph.D., Department of Biology, Wesleyan University, Middletown, Connecticut 06459-0170, USA. Telephone: 860-685-3238; Fax: 860-685-3279; e-mail: lgrabel{at}wesleyan.edu

Received February 21, 2006; accepted for publication June 15, 2006.
First published online in STEM CELLS EXPRESS   June 22, 2006.



Despite the identified therapeutic potential of embryonic stem cells for treating human disease and injury, a number of roadblocks, scientific and ethical, stand in the way of progress toward this goal. We identify six areas of particular interest: tumorigenicity, animal product contamination, genetic compatibility, funding, cell type for transplantation, "embryo-friendly" derivation methods and discuss avenues for moving beyond the difficulties.




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[Abstract] [Full Text] [PDF]


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