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International Journal of Cell Cloning, Vol 3, 149-155, Copyright © 1985 by AlphaMed Press

ORIGINAL ARTICLES

The amount of mobilizable stem cells in perturbed hemopoiesis

J Gidali and I Feher

The level of mobilizable 9-day colony-forming units (CFU-s), which represents a constant fraction of the normal mouse bone marrow CFU-s pool, was assayed in BDF1 mice with perturbed hemopoiesis (i.e., during increased turnover of CFU-s or increased CFU-s traffic after irradiation). After low-level irradiation, regeneration of the mobilizable CFU-s fraction was significantly slower than that of bone marrow CFU-s. Depletion of the mobilizable CFU-s pool was observed if a permanently increased outflow of CFU-s from the bone marrow was induced by endotoxin injection. After 40% withdrawal of the blood volume, the mobilizable CFU-s pool expanded marginally. Assuming that the level of mobilizable CFU-s is a consequence of production and outflow from the bone marrow compartment, changes in the pool size of mobilizable CFU-s may be a sensitive indicator of balanced or unbalanced hemopoiesis.




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STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
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Copyright © 1985 by AlphaMed Press.