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International Journal of Cell Cloning, Vol 3, 388-398, Copyright © 1985 by AlphaMed Press

ORIGINAL ARTICLES

Comparative studies on the characteristics of proliferation and differentiation of spleen colony-forming cells

CT Wu, MP Liu and JP Chu

Using a single spleen colony transplantation technique and sex chromosome typing as a natural cytogenetic marker, most spleen colony- forming cells (CFC) in adult bone marrow or fetal livers of inbred LACA or C57 mice re-established hemopoiesis in lethally irradiated mice when the spleen colonies were sampled at 13 days after transplantation. However, most of the spleen colony-forming cells in the peripheral blood of normal mice possess little potential for proliferation and are less efficient in the re-establishment of hemopoiesis in lethally irradiated mice. The CFC population is heterogeneous in the mice. From the subsequent retransplantation of colonies from colony-forming cells in the peripheral blood, the simple assessment of spleen colony-forming units (CFU-s) content, based on the number of splenic colonies, does not reliably represent the content of hemopoietic stem cells.




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STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
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Copyright © 1985 by AlphaMed Press.