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International Journal of Cell Cloning, Vol 4, 186-191, Copyright © 1986 by AlphaMed Press

ORIGINAL ARTICLES

In vitro growth of erythropoietic progenitor cells in long-term remission of acute leukemia

C Peschel, G Konwalinka, D Geissler and H Braunsteiner

In vitro growth of CFU-e and BFU-e in bone marrow and of circulating BFU-e in a group of adult long-term survivors of acute leukemia has been evaluated. Six patients with acute nonlymphoblastic and three patients with acute lymphoblastic leukemia in first continuous remission for more than four years (range 4-12 years) and without maintenance therapy for at least one year were studied. BFU-e and CFU-e growth in patients' bone marrow was not statistically different from a control group of 12 healthy adult volunteers. However, proliferation of BFU-e in peripheral blood of patients was significantly reduced (p less than 0.001). This growth pattern was found in both lymphoblastic and myeloblastic leukemia.




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