International Journal of Cell Cloning, Vol 4, 378-405, Copyright © 1986 by AlphaMed Press
Biomolecule-cell interactions and the regulation of myelopoiesis
HE Broxmeyer
The regulation of myelopoiesis in vivo most likely entails a complex set of
interactions between cell-derived biomolecules and their target cells. Much
of what we currently know of these interactions has been derived from
studies in vitro utilizing techniques for the purification of both the
biomolecules and the cells producing and responding to these factors.
Stimulating and suppressing influences have been uncovered, and with the
cloning and purification of biologically active factors, studies assessing
the actions of these molecules in vivo have begun. From studies in vitro it
is apparent that many of the purified molecules can have move than one
action and that different molecules can collaborate in a synergistic manner
to enhance or suppress functional endpoints.
