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International Journal of Cell Cloning, Vol 5, 432-449, Copyright © 1987 by AlphaMed Press

REVIEWS

The regulation of hematopoiesis following bone marrow transplantation

SG Emerson and RP Gale
Division of Hematology/Oncology, University of Michigan Medical Center, Ann Arbor 48109.

Allogeneic bone marrow transplantation requires that donor stem cells home to the recipient bone marrow, proliferate and differentiate under normal physiologic regulatory mechanisms. Recent observations that T cell depletion of donor bone marrow leads to a greatly increased incidence of graft failure mandate a detailed understanding of the engraftment process. Post-transplant hematopoietic deficiencies appear to be related to several sources: decreased number of stem cells, activation of donor hematopoietic suppressor cells, rejection of donor stem cells by residual recipient lymphocytes and abnormal function of accessory cells that produce hematopoietic growth factors. A better understanding of the relative roles of these factors should lead to a better understanding of engraftment as well as graft failure and its prevention.




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Copyright © 1987 by AlphaMed Press.