Stem Cells http://www.peprotech.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yi, S. N.
Right arrow Articles by Xu, Y. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Yi, S. N.
Right arrow Articles by Xu, Y. H.

International Journal of Cell Cloning, Vol 6, 290-295, Copyright © 1988 by AlphaMed Press

ORIGINAL ARTICLES

The influence of histamine at various concentrations on the cell cycle state of hematopoietic stem cells (CFU-s)

SN Yi and YH Xu
Research Laboratory of Blood Physiology, Hunan Medical College, Changsha, PRC.

The influence of histamine at various concentrations on the cell cycle state of hematopoietic stem cells (CFU-s) was investigated. CFU-s were triggered from the G0 state into the S phase of the cell cycle by in vitro treatment of mouse bone marrow cells with high concentrations of histamine. This effect could be antagonized by a histamine H2 receptor blocking agent. When bone marrow cells were treated with a histamine H1 receptor antagonist prior to histamine treatment, low concentrations of histamine also triggered the entrance of CFU-s into the DNA synthetic phase. Our findings further suggest the existence of histamine H1 and H2 receptors on the surface of CFU-s cells and the antagonistic effect of these two histamine receptor subtypes on the cell cycle state of CFU- s. Our results also suggest that histamine may participate in regulating the proliferation of hematopoietic stem cells in vivo during immune or inflammatory responses.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Koarai, M. Ichinose, S. Ishigaki-Suzuki, S. Yamagata, H. Sugiura, E. Sakurai, Y. Makabe-Kobayashi, A. Kuramasu, T. Watanabe, K. Shirato, et al.
Disruption of L-Histidine Decarboxylase Reduces Airway Eosinophilia but not Hyperresponsiveness
Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 758 - 763.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.peprotech.com/
Copyright © 1988 by AlphaMed Press.