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International Journal of Cell Cloning, Vol 6, 341-351, Copyright © 1988 by AlphaMed Press

ORIGINAL ARTICLES

Phenotypic instability of tumor cell clones: clonal expression of Fc receptors in the human leukemic K562 cell line and its relationship with hemoglobin expression

P Jeannesson, B Gerard, JC Jardillier and J Bernard
Faculte de Pharmacie, Laboratoire de Biochimie, Reims, France.

Membrane expression of Fc receptors (FcR) was studied in clones of human K562 cells during short- and long-term culture. Using a manual cloning method, well-defined clones were generated either from FcR- positive or FcR-negative cells. The fourth day after cloning, the majority of cloned cells manifested shifts in FcR expression without evidence of an orderly pattern. After long-term culture (about 34 passages), most clones expressed FcR values close to those found in the cell line. In addition, the selection of six clones expressing a stable FcR phenotype suggested that the presence of FcR is correlated to a low hemoglobinization of the multipotential K562 cells.




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