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International Journal of Cell Cloning, Vol 6, 352-364, Copyright © 1988 by AlphaMed Press

ORIGINAL ARTICLES

General characterization of human cytomegalovirus-specific proliferative CD4+ T cell clones

YN Liu, J Eckhardt, B Kari and RC Gehrz
Sutton Immunobiology Research Laboratory, Children's Hospital, St. Paul, Minnesota 55102.

Over 80 human T helper cell (Th) clones reactive with human cytomegalovirus (HCMV) were generated using purified whole Towne strain HCMV as the in vitro antigen. These cloned T cells are CD3+, CD4+, CD8- and proliferate specifically to HCMV. All of the clones tested produce interleukin 2 and gamma-interferon and failed to show HCMV-specific cytotoxicity or natural killer (NK) activity. Most of the Th clones recognize multiple laboratory-adapted and wild-type strains of HCMV. The Th clones were also tested for their reactivity to a major envelope glycoprotein complex (gcI) and a 64,000 dalton internal matrix protein. Our results show that both proteins as well as other unidentified protein(s) are involved in Th responses to HCMV.




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