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International Journal of Cell Cloning, Vol 6, 404-416, Copyright © 1988 by AlphaMed Press

ORIGINAL ARTICLES

Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states

JL Liesveld, CN Abboud, FT Slovick, JM Rowe and JK Brennan
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

The growth of eosinophil progenitors (CFU-Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL-1), and interleukin 2 (IL-2) in three cases of eosinophilia are reported in this paper. One microM HC decreased the proportion of CFU-Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU-Eo. As studied in two of the three cases, IL-1 and IL-2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell-depleted marrow cells were used as the target population. These results suggest that CFU-Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.




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