International Journal of Cell Cloning, Vol 7, 2-12, Copyright © 1989 by AlphaMed Press
Lymphoid cell regulation of hematopoiesis [published erratum appears in Int J Cell Cloning 1989 Mar;7(2):138]
K Pantel and A Nakeff
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201.
It is clear from extensive in vitro data that different subsets of
lymphocytes stimulate and inhibit the growth of hematopoietic stem and
progenitor cells. In order to clarify the complexity of the network between
regulatory lymphocytes and hematopoietic target cells, we have examined the
stimulatory and inhibitory effects derived from different lymphoid subsets.
The regulatory influence of lymphocytes is transmitted mainly through the
release of cytokines including the interleukins, granulocyte-macrophage
colony-stimulating factor, tumor necrosis factor-beta and the interferons,
all of which have non- specific effects on a variety of hematopoietic
cells. Since these cytokines amplify the effects of other, more
lineage-specific cytokines (e.g., erythropoietin, thrombopoietin and
granulocyte or macrophage colony-stimulating factor) on the proliferation
and differentiation of progenitor cells, the present review supports the
conclusion that lymphoid subsets play a critical role in ensuring an
optimal hematopoietic response to specific demands.
