Stem Cells http://www.peprotech.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brach, M. A.
Right arrow Articles by Herrmann, F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Brach, M. A.
Right arrow Articles by Herrmann, F.

International Journal of Cell Cloning, Vol 9, 89-94, Copyright © 1991 by AlphaMed Press

ORIGINAL ARTICLES

Expression of the c-fes proto-oncogene in granulocyte-macrophage colony- stimulating factor-dependent acute myelogenous leukemia cells grown autonomously

MA Brach, E Gauer, WD Ludwig, A Ganser, R Mertelsmann and F Herrmann
Department of Hematology, University of Freiburg, Federal Republic of Germany.

In the present article, we show that 6 of 69 acute myelogenous leukemia (AML) samples exhibited autonomous in vitro growth that was dependent on endogenous granulocyte-macrophage colony-stimulating factor (GM- CSF). Cytoplasmic RNA harvested from all 6 leukemia specimens contained GM-CSF transcripts easily detectable by mRNA hybridization. All 6 GM- CSF-expressing leukemia samples simultaneously displayed high levels of transcripts for the c-fes proto-oncogene previously shown to be expressed in GM-CSF sensitive myeloid cells, whereas only 2 of the 48 AML samples not expressing GM-CSF accumulated c-fes mRNA. Seven of additional 14 GM-CSF-expressing specimens showed specific signals upon RNA hybridization with the c-fes probe, but failed to grow autonomously. These results suggest that c-fes and GM-CSF genes may be coordinately regulated in AML blasts and that GM-CSF-mediated growth autonomy may be linked to c-fes expression.


This article has been cited by other articles:


Home page
 Cold Spring Harb Symp Quant BiolHome page
J. LOSMAN, X.P. CHEN, H. JIANG, P.-Y. PAN, M. KASHIWADA, C. GIALLOURAKIS, S. COWAN, K. FOLTENYI, and P. ROTHMAN
IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCS Proteins to the Receptor Complex
Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 405 - 416.
[Abstract] [PDF]

Home page
 BloodHome page
M. Jucker, C. A. Schiffer, and R. A. Feldman
A Tyrosine-Phosphorylated Protein of 140 kD Is Constitutively Associated With the Phosphotyrosine Binding Domain of Shc and the SH3 Domains of Grb2 in Acute Myeloid Leukemia Cells
Blood, March 15, 1997; 89(6): 2024 - 2035.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Yates, G. Crooks, and J. Gasson
Analysis of Fes kinase activity in myeloid cell growth and differentiation
Stem Cells, November 1, 1996; 14(6): 714 - 724.
[Abstract]

Home page
 Stem CellsHome page
K. Yates and J. Gasson
Role of c-Fes in normal and neoplastic hematopoiesis
Stem Cells, January 1, 1996; 14(1): 117 - 123.
[Abstract]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS

Copyright © 1991 by AlphaMed Press.