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International Journal of Cell Cloning, Vol 9, 531-541, Copyright © 1991 by AlphaMed Press

REVIEWS

Clinical applications of human granulocyte-macrophage colony- stimulating factor

KM Sakamoto and JC Gasson
Department of Pediatrics, UCLA School of Medicine 90024-1752.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates myeloid cell proliferation and maturation and enhances the function of terminally differentiated effector cells. Phase I and II clinical trials have demonstrated mild to moderate toxicities at doses of less than 30 micrograms/kg/day. These studies suggest a potential role for this growth factor to stimulate myelopoiesis in patients with aplastic anemia, myelodysplastic syndromes, AIDS, chemotherapy-induced myelosuppression, chronic neutropenia, and following bone marrow transplantation. The potential clinical uses of GM-CSF will depend on results of studies designed to optimize its therapeutic efficacy.


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H.-J. J. Lee, R. C. Mignacca, and K. M. Sakamoto
Transcriptional Activation of egr-1 by Granulocyte-Macrophage Colony-stimulating Factor but Not Interleukin 3 Requires Phosphorylation of cAMP Response Element-binding Protein (CREB) on Serine 133
J. Biol. Chem., July 7, 1995; 270(27): 15979 - 15983.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by AlphaMed Press.